RPSC Assistant Professor- Pathology Written Exam Syllabus & Pattern

RPSC Assistant Professor (Pathology) Medical & Health Department Recruitment exam is being scheduled in the state for which the syllabus and pattern of the exam is an important things to be learned. RPSC Assistant Professor Pathology Exam Syllabus & Pattern details for the latest exam are mentioned below. This will help you prepare a schedule for the exam and score high on the exam paper.

For Assistant Professor In Pathology, RPSC conducts a screening test that includes certain topics in the syllabus. Every candidate has to prepare in the best possible way for the exam.

RPSC Assistant Professor Pathology Exam Pattern

A written Test is conducted, which contains all multiple choice questions.

Total Questions: 100

Total Marks: 100 Marks

Total Time Given: 2 Hours

NOTE: Negative Marking will be done in the exam paper.

RPSC Assistant Professor Pathology Exam Syllabus

The questions in the Assistant professor Pathology Exam contain the questions from topics-

  • Role of Immuno histochemistry in problematic prostate biopsy
  • Cytokeratin immunostaining profile in diagnostic pathology
  • Pathology of regenerative and neoplastic hepatocellular nodules
  • Serrated lesions of the colon and rectum
  • An update on the pathology of chronic inflammatory bowel disease
  • Diagnosis and therapy of gastrointestinal MALT lymphoma
  • Medical revalidation for histopathologists
  • Molecular testing for human papillomavirus
  • Tensions in health and disease
  • Pathology in the undergraduate curriculum
  • The maternal death autopsy
  • Classification and treatment of non-small-cell lung carcinoma
  • Pathology of obesity
  • Stratified medicine for cancer: the role of the histopathologist
  • Primary carcinoma of the salivary gland –Selected Recent Advances
  • Cancer invasion and metastasis -The concept of epithetial mesenchymal transition
  • Matrix metalloproteinases (MMP) in neoplastic progression –Where are we now?
  • Osteoarthritis–New concepts
  • Cutaneous pseudo lymphoma
  • Liquid-based cytology for Cervical Screening
  • Pitfall in the diagnoses of Soft tissue tumors of childhood
  • Sudden unexpected death in Infancy
  • The Non- invasive or minimally invasive autopsy
  • Antibody-mediated rejection of solid organ allografts
  • Mucosal pathology of the gastric cardia and Barrett’s oesophagus
  • Bio-terrorism.
  • Predictive and prognostic molecular markers in breast cancer
  • Digital photography in histopathology
  • Adult stem cells and transdifferentiation

The topics details for the RPSC Bio Chemist Exam are-

Cell Injury

  • Extracellular accumulation: Amyloidosis, classification, pathogenesis, morphology
  • Irreversible cell injury: Types of necrosis, gangrene
  • Calcification : Dystrophic and metastatic
  • Cause and mechanism: Ischemic, Toxic and Apoptosis
  • Reversible cell injury: Types, morphology, hyaline, fatty change

Inflammation and repair

  • Wound healing by the primary and secondary union factors are promoting and delays the process, and complications.
  • The morphological variant of acute inflammation.
  • Acute inflammation- features, causes, vascular and cellular events.
  • Inflammatory cells and mediators.
  • Chronic inflammation- causes, types, non-specific and granulomatous with common examples.


  • Hypersensitivity with its types and examples, antibodies and cells mediated tissue injury with examples.
  • Organ transplantation including immunological basis of rejection and graft versus host reaction.
  • Immune pathology- organization, cells, antibodies and regulations of immune responses.
  • Autoimmune disorders like Systemic Lupus Erythematosus.

Infectious diseases

  • Mycobacterial diseases such as tuberculosis and leprosy
  • AIDS- etiology, modes of transmission, pathogenesis, pathology, complications, diagnostic procedures and handling of infected materials and health education
  • Fungal disease and opportunistic infections
  • Parasitic diseases- Malaria, filarial, amoebiasis, kala azar, cystecercosis, hydatid
  • Bacterial diseases such as pyogenic, typhoid, diphtheria, gram-ve infections, bacillary dysentery, syphilis
  • Viral- polio, herpes, rabies, measles, reckettsial, chlamydial infections

Circulatory disturbances

  • Thrombosis and embolism- formation, fate and effects
  • Shock pathogenesis, types, morphological changes
  • Oedema- Pathogenesis and types
  • Infarction types, common sites, gangrene
  • Chronic venous congestion in lung, liver, spleen

Growth disturbances

  • Atrophy, hypertrophy, malformation, agenesis, dysplasia, hyperplasia, hypoplasia, metaplasia
  • Malignant neoplasia grades and stages, local and distant spread
  • Carcinogenesis as Environmental carcinogen, chemical, viral, occupational, hereditary and basics of molecular basis of cancer
  • Tumor and host interaction- Systemic effects including para neoplastic syndrome, tumour immunology
  • Laboratory diagnosis-cytology, biopsy, tumor markers
  • Tumors and tumor like conditions of soft tissues
  • Neoplasia causes, classification, histogenesis, biological behaviour, benign and malignant, carcinoma and sarcoma

Miscellaneous disorders

  • Disorders of pigments and mineral metabolism such as billirubin, melanin, haemosiderin
  • Protein energy malnutrition and vitamin deficiency disorders
  • Autosomal and sex-linked disorders with examples
  • Radiation injuries


  • Acquired Hemolytic anemia- malaria, Kala Azar., Autoimmune, alloimmune, drug induced, microangiopathic
  • Anemia- Classification and clinical features
  • Haemolytic anemia classification and investigation
  • Herediatary haemolytic anemia- thalassemia, sickle cell anemia, hereditary spherocytosis and G 6 PD D deficiency
  • Multiple myeloma and dysprotenemias
  • Nutritional anemia- Iron deficiency, folic acid/ vit. B 12 deficiency anemia including pernicious anemia
  • Coagulopathies : coagulation factor deficiency, hemophilia, DIC and anticoagulant control
  • Leucocytic disorders- Leucocytosis, leucopoenia, leukemoid reaction
  • Myelodysplastic syndrome
  • Blood transfusion grouping and cross matching untoward reactions, transmissible infections including HIV and hepatitis
  • Myelo proliferative disorders polycythemia, myelofibrosis
  • Haemostatic disorders- platelet deficiency, ITP, drug induced, secondary
  • Acute and chronic leukemia classification and diagnosis

Cardiovascular Pathology

  • Pericarditis
  • Acute Rheumatic fever- etiopathogenesis and morphological changes and complications including rheumatic heart disease
  • Congenital heart disease- ASD, VSD, Fallot’s tetatology, Biscuspid aortic Valve PDA
  • Hypertension and hypertensive heart disease
  • Infective endocarditis- etiopathogenesis and morphological changes and complications
  • Atheroscelorosis and ischemic heart disease- myocardial infarction
  • Cardiomyopathy

Respiratory Pathology

  • Atelectasis and hyaline membrane disease
  • Emphysema types and pathogenesis
  • Pneumonias- lobar, broncho, interstitial
  • Lung abscess- etiopathogenesis and morphology and complications
  • Pulmonary tuberculosis- primary and secondary, morphologic types Including pleuritis
  • Nasopharyngeal and laryngeal tumors
  • Structure of bronchial tree and alveolar walls, normal and altered inflammatory diseases of bronchi (chronic bronchitis, bronchiectasis)
  • Tumours (Epithelial Malignant Neoplasms of Lung, Etiopathogenesis
  • Concepts of obstructive and restrictive lung disorders –Chronic bronchitis, emphysema, Asthma)
  • Occupational lung disorders- anthracosis, silicosis, asbestosis, mesothelioma

Renal & Urinary Tract Pathology

  • Basics of impaired function and urinalysis
  • Urinary Bladder- Cystitis, carcinoma
  • Acute renal failure- acute tubular and cortical necrosis
  • Pyelonephritis, reflux nephropathy, interstitial nephritis
  • Renal cell tumors-Renal cell carcinoma, Nephroblastoma
  • Clinical presentation of renal disorders including nephritic, nephrotic syndrome, acute renal failure, recurrent hematuria, CRF
  • Renal malformation polycystic kidney
  • Urinary tract tuberculosis
  • Progressive renal failure and end stage renal disease
  • Glomerulonephritis includes Classification, primary proliferative and non- proliferative, secondary (SLE, polyarteritis, amyloidosis, diabetes mellitus)
  • Renal vascular disorders
  • Nephrolithiasis and obstructive nephropathy

Pathology Of Gastrointestinal Tract

  • Pancreatitis
  • Tumors of Stomach : Benign, polyp, leiomyoma, malignant, adenocarcinoma, other gastric tumors
  • Inflammatory disease of large Intestine- Amoebic colitis, bacillary dysentery, ulcerative colitis
  • Oral pathology-Leukoplakia, carcinoma oral cavity and esophagus
  • Ischemic and pseudomembranous enterocolitis, diverticulitis
  • Peptic Ulcer- Etiopathogenesis and complications, gastritis types
  • Pancreatic tumors- endocrine, exocrine and pariampullary
  • Inflammatory disease of small Intestine- Typhoid, tuberculosis, Crohn’s disease, appendicitis
  • Large and small intestine tumors- polyps, carcinoid, carcinoma, lymphoma
  • Salivary gland tumors
  • Malabsorption-coeliac disease, tropical sprue and other causes

Liver And Billiary Tract Pathology

  • Jaundice types, etiopathogenesis and differentiation
  • Hepatitis- Acute and chronic, etiology, pathogenesis and pathology
  • Cirrhosis- Etiology, classification, pathology, complications
  • Portal Hypertension types and manifestation
  • Diseases of gall Bladder- Cholecystitis, cholelithiasis, carcinoma
  • Tumors of liver-Hepatocelluler, metastatic, tumor markers

Lymphoreticular System

  • Diseases of spleen-splenomegaly and effects
  • Lymphadenitis non-specific, granulomatous, Hodgkin’s lymphoma
  • Non-Hodgkin’s lymphoma, classification, morphology

Reproductive system

  • Ovarian and testicular tumors
  • Carcinoma of penis
  • Pelvic inflammatory disease including salpingitis
  • Diseases of cervix- cervicitis, cervical carcinoma, etiology, cytological diagnosis
  • Hormonal influences and histological appearances of different phases of menstrual cycles and the abnormality associated with it
  • Genital tuberculosis
  • Diseases of uterus- endometrial hyperplasia and carcinoma, adenomyosis, smooth muscle tumors
  • Trophoblastic diseases- Hydatiform mole and choriocarcinoma
  • Diseases of Breast include mastitis, abscess, fibrocystic disease, neoplastic lesions, fibroadenoma, carcinoma, phyllodes tumors
  • Prostate-Nodular hyperplasia, carcinoma


  • Arthritis- Rheumatoid, osteoid and tuberculosis
  • Metabolic diseases- rickets/osteomalacia, osteoporosis, hyper parathyroidism
  • Healing of fractures
  • Osteomyelities- acute, chronic, tuberculosis
  • Tumors- primary, osteosarcoma, osteoclastoma, Ewing’s sarcoma, chondro sarcoma, metastatic

Endocrine pathology

  • Diabetes mellitus types, pathogenesis, pathology
  • Non neoplastic lesion of thyroid- Iodine deficiency goiter, autommune thyroiditis, thyrotoxicosis, myxoedema
  • Parathyroid hyperplasia and tumors
  • Tumors of thyroid- adenoma, carcinoma: pappilary, follicular, medullary, anaplastic
  • Adrenal disease- cortical hyperplasia, atrophy, tuberculosis, tumors of cortex and medulla


  • Inflammatory disorders- pyogenic and tubercular meningitis, brain abscess, tuberculoma
  • CNS tumors-primary glioma and meningioma and metastatic
  • CSF and its disturbances cerebral oedema, raised intracranial pressure
  • Cerebrovascular disease atherosclerosis, thrombosis, embolism, aneurysm, hypoxia, infarction and hemorrhage


  • Skin tumors such as squamous cellcarcinoma, basal cellcarcinoma, and melanoma
  • adenexial tumours with common non neoplastic skin diseases

Tumors of soft tissues

  • Routine processing & frozen sections
  • Ancilliary Immunohistochemistry, diagnostic tests, tumour markers & their interpretation

Molecular genetics

  • Hybrid DNA techniques
  • Application in diseases


  • Buccal smears for Sex chromatin bodies
  • Collection procedures and diagnosis interpretation
  • Fine Needle Aspiration Cytology
  • Imprint, crush smear, biopsy sediment cytology
  • Exfoliative cytology of body fluids, urinary tracts, female genital tract, Ammiotic fluid & tears

Laboratory Hi-Tech Instruments

  • Fluorescent Microscope & Electrophoresis
  • High performance liquid Chromatography (HPLC)
  • Technical Procedures, principles and clinical interpretation of tests using
  • Haematology auto-analysers, Flow-Cytometer, Polymerase chain reaction (PCR)
  • Electrochemiluminiscent immunoassay (ECLIA)
  • Electron Microscope, Phase Contrast Microscope

Rational use & safe Blood Transfusion Blood banking procedures & preparation of Blood Components with their storage

Lab Biomedical Waste

  • Principles of collection
  • Segregation
  • disposal

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